Preimplantation genetic diagnosis-further divides in to two categories
PGT-M and PGT-SR
PGTM, or preimplantation genetic testing for mutatationwas formerly known as preimplantation genetic diagnosis (PGD).PGT-M detects single gene defects or monogeneicdisorders. PGT-M,is mainly for people who know that they are at an increased risk of passing a specific genetic condition to their children.
It is for people who are carriers for an autosomal recessive condition (Eg: Thalassemia)
Women who are carriers for X linked condition( Eg: Duchenne muscular dystrophy)
Either you or your partner are affected with an autosomal dominant condition. (Eg: Marfan syndrome)
You had a child or pregnancy with a single gene disorder
PGT-SR, or preimplantation genetic testing for chromosomal structural rearrangements. It is a genetic testing for structural chromosomal rearrangements, which can be performed to improve the possibility of establishing a healthy pregnancy.
People with chromosome rearrangements are at an50% risk of producing embryos with an incorrect amount of genetic material, resulting in deletion/ duplication syndrome which typically does not lead to a successful pregnancy.
It is recommendedfor people with
Carriers of balanced translocation, Robertsonian translocation
ICSI followed by embryo culture
Screened for PGT-A/PGT-M/PGT-SR
Embryo transfer: Transfer of a genetically healthy embryo