PICSI is a treatment done for male factor infertility when the sperms are fragmented. This increased sperm DNA fragmentation is seen in men with varicocele, infections, advanced age, smoking, obesity and poor lifestyle.
PICSI is used as a method to select sperms, (For ICSI) which do not have a fragmented DNA. A solution of Hylauronin is used to coat the dish used for PICSI. The good quality sperms stock to the solutions, Which can be picked up by the embryologist to be used for ICSI.