Preimplantation genetic diagnosis (PGD) is a diagnostic technique that allows us to detect genetic abnormalities in the embryo before its transfer to the mother’s uterus. Its goal is to prevent the transmission of some diseases or heritable genetic damages.

After IVF is done and before the embryo is transferred into the uterus, the genetic material is studied to screen possible genetic alterations. This is performed when the embryo reaches the blastocyst stage on day 5-6 of its development. It is at this phase when a biopsy is carried out in every embryo and those that contain chromosomal abnormalities or any particular hereditary disease are dismissed. After the biopsy, the embryos are frozen and afterwards up to 3 are transferred.

PGD is recommended in those cases in which there is a chromosomal risk for the embryo, such as:

• Couples with recurrent miscarriage
• Women of advanced reproductive age
• Implantation failure
• Genetic male factor

It is also recommended to avoid the transmission of any genetic disease for which both parents are carriers.